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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

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In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Related Experiment Video

Updated: Apr 29, 2026

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults
08:56

Clinical Assessment of Spatiotemporal Gait Parameters in Patients and Older Adults

Published on: November 7, 2014

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[Gait disorders in the elderly].

K Amadori1, R Püllen, T Steiner

  • 1Klinik für Neurologie, Klinikum Frankfurt Höchst, Gotenstr. 6-8, 65929, Frankfurt am Main, Deutschland, kerstin.amadori@klinikumfrankfurt.de.

Der Nervenarzt
|May 29, 2014
PubMed
Summary
This summary is machine-generated.

Gait disorders are common in older adults, increasing fall risks. Comprehensive diagnosis and multiprofessional treatment are crucial for managing mobility impairments and preventing injuries.

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Related Experiment Videos

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Area of Science:

  • Gerontology
  • Neurology
  • Movement Science

Context:

  • Gait disorders are a prevalent gerontoneurological symptom in the elderly.
  • Falls associated with gait disorders can lead to severe injuries.
  • Diagnosis involves clinical neurological examination and gait analysis.

Purpose:

  • To summarize the diagnostic and therapeutic challenges of gait disorders in the elderly.
  • To highlight the importance of identifying and modifying risk factors.
  • To outline a multiprofessional therapeutic approach.

Summary:

  • Gait disorders in the elderly present multifactorial causes, complicating identification and treatment.
  • Diagnostic process includes neurological examination, gait analysis, and motor assessments.
  • Therapeutic strategies involve treating underlying diseases, physiotherapy, medical aids, and nutritional interventions.

Impact:

  • Improved identification and management of gait disorders can reduce fall-related injuries in older adults.
  • Multiprofessional interventions are key to addressing the complexity of elderly gait impairments.
  • Focus on risk factor modification is essential for effective prevention and treatment strategies.