Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
Bone Remodeling01:40

Bone Remodeling

34.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hybrid Whole-Genome Sequencing of <i>Penicillium crustosum</i> CTM10622 Uncovers a Highly Thermostable Alkaline Serine Lipase with Biotechnological Relevance.

International journal of molecular sciences·2026
Same author

Bioactive levan polysaccharides in cosmeceutical applications: A review.

International journal of biological macromolecules·2026
Same author

A new strategy to separate peptide methionine sulfoxides stereoisomers for potential immunotherapy application.

Analytical and bioanalytical chemistry·2026
Same author

Exploring the therapeutic potential of cannabidiol in soft tissue wound healing: Delivery strategies and anti-inflammatory pathways.

Acta pharmaceutica Sinica. B·2026
Same author

Laser-Engineered Multilayer Coatings Based on Zinc Oxide and Lovastatin-Functionalized Bioactive Glasses for Corrosion-Resistant and Antimicrobial Stainless Steel Implants.

Biomimetics (Basel, Switzerland)·2026
Same author

Corrigendum to "Functional bread containing synbiotic microcapsules loaded with Lactobacillus delbrueckii subsp. bulgaricus and enzymatic levan" [Food Chem. 511 (2026) 148823].

Food chemistry·2026

Related Experiment Video

Updated: Apr 29, 2026

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

4.0K

Combinatorial MAPLE gradient thin film assemblies signalling to human osteoblasts.

Emanuel Axente1, Felix Sima, Livia Elena Sima

  • 1Lasers Department, National Institute for Lasers, Plasma and Radiation Physics, 409 Atomistilor Street, Magurele, Ilfov RO-77125, Romania.

Biofabrication
|May 29, 2014
PubMed
Summary

Researchers developed a new method to create bioactive material films with a compositional gradient. This material can control cell signaling, offering potential for tissue engineering and regenerative medicine applications.

More Related Videos

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

6.7K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.8K

Related Experiment Videos

Last Updated: Apr 29, 2026

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate
10:32

Author Spotlight: Simple Establishment of a Vascularized Osteogenic Bone Marrow Niche Using Pre-Cast Poly(Ethylene Glycol) (PEG) Hydrogels in an Imaging Microplate

Published on: May 19, 2023

4.0K
A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling
08:28

A Lab-On-A-Chip Platform for Stimulating Osteocyte Mechanotransduction and Analyzing Functional Outcomes of Bone Remodeling

Published on: May 21, 2020

6.7K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.8K

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Cell Biology

Background:

  • Smart bioactive materials are crucial for engineering cell-instructive scaffolds in tissue regeneration.
  • Controlling material composition is key to directing cellular responses for regenerative applications.

Purpose of the Study:

  • To introduce and validate combinatorial matrix-assisted pulsed laser evaporation (C-MAPLE) for fabricating gradient biopolymer films.
  • To investigate the cellular response, specifically osteoblast attachment and signaling, to a compositional gradient.

Main Methods:

  • Fabrication of a two-compound biopolymer film (levan and oxidized levan) using synchronized C-MAPLE.
  • Validation of the compositional gradient using fluorescence microscopy.
  • Analysis of early osteoblast attachment and extracellular signal-regulated kinase (ERK) signaling pathway modulation.

Main Results:

  • The compositional gradient of the biopolymer film was successfully fabricated and validated.
  • Osteoblast attachment was directly proportional to the concentration of oxidized levan in the gradient.
  • Specific regions of the gradient modulated osteoblast ERK signaling differently.

Conclusions:

  • The C-MAPLE method enables the creation of novel bioactive materials with controlled compositional gradients.
  • These materials can effectively modulate cell signaling pathways, showing promise for tissue regeneration.
  • This approach provides a platform for screening bioactive interfaces for regenerative medicine.