Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

1.4K
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
1.4K
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

1.0K
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
1.0K
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

987
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
987
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

900
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
900
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

912
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
912
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists01:23

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

1.4K
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
1.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inflammatory bowel diseases patients' perspective on the impact of pathologic evaluation: an 'AMICI' initiative.

European journal of gastroenterology & hepatology·2025
Same author

Histological healing in IBD: Ready for prime time?

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2025
Same author

Colonic motility investigation by modern techniques: time to 'reclaim' the value of physiology?

Gut·2024
Same author

Clinical and endoscopic findings in patients with acute gastrointestinal bleeding associated with direct oral anticoagulants: Results from a single-center prospective cohort study.

Thrombosis research·2024
Same author

Mucosal Healing in Inflammatory Bowel Diseases: Still too Many Irons on the Fire.

United European gastroenterology journal·2024
Same author

A retrospective analysis of alimentary tract duplications in pediatric patients: a 14-year single-center experience.

Pediatric surgery international·2024

Related Experiment Video

Updated: Apr 29, 2026

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

3.6K

Understanding and treating refractory constipation.

Gabrio Bassotti1, Corrado Blandizzi1

  • 1Gabrio Bassotti, Gastroenterology and Hepatology Section, Department of Medicine, University of Perugia, 06156 Perugia, Italy.

World Journal of Gastrointestinal Pharmacology and Therapeutics
|May 29, 2014
PubMed
Summary
This summary is machine-generated.

Many chronic constipation cases are treatable with proper evaluation, avoiding misdiagnosis of treatment resistance. Personalized strategies for slow transit or obstructed defecation improve outcomes, with advanced options for refractory cases.

Keywords:
Chronic constipationLaxativesMedical treatmentRefractory constipationSurgical treatment

More Related Videos

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

1.3K
Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

2.5K

Related Experiment Videos

Last Updated: Apr 29, 2026

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

3.6K
Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

1.3K
Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

2.5K

Area of Science:

  • Gastroenterology
  • Clinical Medicine
  • Pharmacology

Background:

  • Chronic constipation is a common clinical issue.
  • Standard treatments fail for a subset of patients.
  • Apparent treatment resistance may stem from diagnostic errors or inadequate regimens.

Purpose of the Study:

  • To differentiate true refractory constipation from cases of apparent resistance.
  • To guide appropriate diagnostic and therapeutic strategies for chronic constipation.
  • To optimize management for patients with treatment-resistant constipation.

Main Methods:

  • Comprehensive re-evaluation of patients with apparent constipation refractoriness.
  • Diagnostic workup to identify specific constipation subtypes (e.g., slow transit, obstructed defecation).
  • Tailoring treatment based on identified pathophysiology, including pharmacological and non-pharmacological interventions.

Main Results:

  • Re-evaluation identifies treatable causes in many patients initially deemed refractory.
  • Slow transit constipation may respond to stimulant laxatives, enterokinetics (prucalopride), or secretagogues (lubiprostone, linaclotide).
  • Obstructed defecation may benefit from biofeedback; refractory cases may consider neuromodulation, botulinum toxin, or surgery with variable outcomes.

Conclusions:

  • Accurate diagnosis is crucial for managing chronic constipation.
  • Personalized treatment based on constipation subtype improves patient outcomes.
  • Advanced interventions offer options for select patients with true treatment resistance.