Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

3.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.9K
Bone Remodeling01:40

Bone Remodeling

34.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
34.3K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

3.5K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.5K
Bone Disorders01:29

Bone Disorders

8.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
8.0K
Bone Remodeling and Repair01:31

Bone Remodeling and Repair

9.2K
9.2K
Receptor Downregulation in MVBs01:15

Receptor Downregulation in MVBs

2.0K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Beyond resorption: targeting osteoclast fusion and polarization to restore balanced bone remodeling.

Frontiers in pharmacology·2026
Same author

Real-world comparison of peripheral neuropathy and treatment delivery between Pola-R-CHP and R-CHOP in DLBCL.

British journal of haematology·2026
Same author

Bilateral eyelid erythema and oedema accompanied by systemic lupus erythematosus and syndrome of inappropriate antidiuretic hormone secretion.

Rheumatology advances in practice·2026
Same author

Clinical Images: Marked edema of the left lower leg caused by IgG4-related retroperitoneal fibrosis accompanied by double inferior vena cava.

ACR open rheumatology·2026
Same author

Clinical-grade autonomous cytopathology through whole-slide edge tomography.

Nature·2026
Same author

Perforated Small Intestinal Diffuse Large B-Cell Lymphoma Successfully Managed With Surgical Resection and Staged Introduction of Polatuzumab Vedotin-Based Chemotherapy.

Journal of medical cases·2026

Related Experiment Video

Updated: Apr 29, 2026

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro
07:51

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Published on: March 18, 2019

5.3K

[Cytokine-mediated bone resorption].

Midori Nakamura1, Shunsuke Uehara, Hiroshi Nakamura

  • 1Department of Biochemistry, Institute for Oral Science, Matsumoto Dental University, Japan.

Clinical Calcium
|May 30, 2014
PubMed
Summary

This review explains how cytokines from osteoblasts and inflammatory cells regulate bone resorption. It details the role of these signaling molecules in osteoclastogenesis, the process of bone breakdown.

Area of Science:

  • Cell Biology
  • Immunology
  • Bone Biology

Background:

  • Osteoclasts are multinucleated cells responsible for bone resorption.
  • These cells originate from the monocyte-macrophage lineage.
  • Osteoclastogenesis is a complex process regulated by various factors.

Purpose of the Study:

  • To review the regulatory mechanisms of bone resorption.
  • To summarize the role of cytokines in osteoclastogenesis.
  • To highlight the interplay between osteoblasts and inflammatory cells in bone remodeling.

Main Methods:

  • Literature review of studies on osteoclastogenesis and bone resorption.
  • Analysis of cytokine signaling pathways involved in bone remodeling.
  • Synthesis of information on interactions between osteoblasts and hematopoietic inflammatory cells.

More Related Videos

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.1K
A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

6.5K

Related Experiment Videos

Last Updated: Apr 29, 2026

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro
07:51

Effect of Anti-c-fms Antibody on Osteoclast Formation and Proliferation of Osteoclast Precursor In Vitro

Published on: March 18, 2019

5.3K
A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
11:47

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders

Published on: June 8, 2014

11.1K
A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
07:03

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

Published on: June 16, 2022

6.5K

Main Results:

  • Cytokines derived from osteoblasts and hematopoietic inflammatory cells are key regulators of osteoclastogenesis.
  • Hormones, cytokines, and growth factors influence osteoclast activity through interactions with osteoblasts.
  • Specific cytokines mediate the communication between bone cells and immune cells.

Conclusions:

  • Cytokine signaling is crucial for controlling bone resorption.
  • Understanding these regulatory mechanisms can inform therapeutic strategies for bone diseases.
  • The review consolidates current knowledge on the molecular regulation of bone remodeling.