Related Experiment Video
Updated: Apr 29, 2026
Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
Published on: July 31, 2017
Hyperbaric oxygen preconditioning attenuates postoperative cognitive impairment in aged rats
Li Sun1, Keliang Xie, Changsheng Zhang
1aDepartment of Anesthesia and Operation Center, Chinese People's Liberation Army General Hospital bDepartment of Anesthesiology, Beijing Military Region General Hospital, Beijing cDepartment of Anesthesiology, Tianjin Medical University General Hospital, Tianjin Institute of Anesthesiology, Tianjin, China.
Hyperbaric oxygen (HBO) preconditioning protected elderly rats from surgery-induced cognitive decline. This neuroprotection involved reducing inflammation and improving brain barrier function after surgery.
Area of Science:
- Neuroscience
- Gerontology
- Surgical Research
Background:
- Postoperative cognitive decline is a significant issue in elderly patients.
- Hyperbaric oxygen (HBO) therapy shows promise for neuroprotection.
Purpose of the Study:
- To investigate if HBO preconditioning can prevent cognitive impairment after surgery in elderly rats.
- To explore the underlying mechanisms of HBO's neuroprotective effects.
Main Methods:
- Elderly male rats received HBO preconditioning before a surgical procedure.
- Cognitive function was assessed using fear conditioning and Y-maze tests.
- Blood-brain barrier integrity, cytokine levels, and caspase-3 activity were measured.
Main Results:
- HBO preconditioning significantly prevented surgery-induced cognitive impairment.
- HBO reduced levels of proinflammatory cytokines (TNF-α, IL-1β, IL-6, HMGB1) in serum and hippocampus.
- HBO improved blood-brain barrier integrity and decreased hippocampal caspase-3 activity.
Conclusions:
- HBO preconditioning offers significant neuroprotection against surgery-induced cognitive impairment in the elderly.
- The protective effects are linked to reduced systemic and hippocampal inflammation and apoptosis.
More Related Videos
09:48Quantification of Neurovascular Protection Following Repetitive Hypoxic Preconditioning and Transient Middle Cerebral Artery Occlusion in Mice
Published on: May 4, 2015
07:46Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
Published on: May 9, 2013