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Updated: May 14, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
10:17

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

Deciphering Early Oxidative Steps in Spirotetronate Biosynthesis Reveals a Two-Enzyme Cascade for Macrocyclic Lactone

Siqiang Chen1,2, Zuer Lin1,2, Qingbo Zhang1,2

  • 1State Key Laboratory of Tropical Oceanography, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China.

Organic Letters
|May 13, 2026
PubMed
Summary

Researchers identified key enzymes (PasO4/PasO3) in spirotetronate biosynthesis, creating a cascade for macrocyclic lactone formation. This biocatalytic tool offers new ways to diversify spirotetronate compounds.

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