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Patient-prosthesis mismatch increases the mean platelet volume in patients with aortic valve replacement

Huseyin Bayram1, Mete Hidiroglu, Levent Cetin

  • 1Department of Cardiovascular Surgery, Ataturk Education and Research Hospital, 1426. Cad, No: 30/17, Cukurambar, 06510, Ankara, Turkey, drhuseyinbayram@gmail.com.

Surgery Today
|May 30, 2014
PubMed
Abstract

Insights

Patient-prosthesis mismatch (PPM) is associated with elevated mean platelet volume (MPV), indicating increased platelet activation. This study found higher MPV levels in PPM patients compared to non-PPM patients and healthy individuals.

Area of Science:

  • Cardiology
  • Hematology
  • Biomarkers

Background:

  • Patient-prosthesis mismatch (PPM) occurs when prosthetic valve size is inadequate relative to patient body surface area.
  • Platelet activation is implicated in cardiovascular disease, but its role in PPM is not fully understood.

Purpose of the Study:

  • To investigate mean platelet volume (MPV) as a marker of platelet activation in patients with PPM after aortic valve replacement (AVR).

Main Methods:

  • A study included 109 patients undergoing isolated AVR with mechanical prostheses and 102 healthy controls.
  • Patients were categorized into PPM (n=41) and non-PPM (n=68) groups.
  • Echocardiography and serum MPV measurements were performed on all participants.

Main Results:

  • MPV was significantly higher in AVR patients versus controls (8.97 ± 0.93 vs. 8.26 ± 0.14, p < 0.001).
  • MPV was significantly higher in the PPM group compared to the non-PPM group (9.36 ± 0.61 vs. 8.73 ± 1.01, p < 0.001).
  • Platelet counts did not differ significantly between groups.

Conclusions:

  • PPM patients exhibit significantly higher MPV levels than non-PPM AVR patients and healthy subjects.
  • Elevated MPV in PPM suggests increased platelet activation, potentially contributing to adverse outcomes.

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