Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Preload-responsive, pulsatile-flow, externally valved pump: cardiopulmonary bypass.

T M Runge1, F L Grover, D J Cohen

  • 1Department of Surgery, University of Texas Health Science Center, San Antonio 78284-7842.

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
|January 1, 1989
PubMed
Summary

A new pulsatile pump for cardiopulmonary bypass offers physiologic pulsatility and reduced hemolysis. This device may improve patient outcomes and has potential applications in ventricular assist and hemodialysis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of the serotonin transporter gene in the behavioral expression of autism.

Molecular psychiatry·2001
Same author

Mothers' functioning and children's symptoms 5 years after a SCUD missile attack.

The American journal of psychiatry·2001
Same author

A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder.

The American journal of psychiatry·2001
Same author

3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties.

Bioorganic & medicinal chemistry letters·2001
Same author

Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization.

The New England journal of medicine·2001
Same author

Effect of eptifibatide on coronary flow reserve following coronary stent implantation (an ESPRIT substudy). Enhanced Suppression of the Platelet IIb/IIIa Receptor with Integrilin Therapy.

The American journal of cardiology·2001

Area of Science:

  • Biomedical Engineering
  • Cardiovascular Surgery
  • Medical Devices

Background:

  • Current cardiopulmonary bypass relies on steady-flow pumps (roller, centrifugal), contributing to procedure morbidity and mortality.
  • Physiologic pulsatile flow is essential for optimal outcomes, including normal systemic resistance and reduced lactate production.
  • Previous pulsatile pump designs have faced challenges in clinical application.

Purpose of the Study:

  • To introduce a novel pulsatile pump designed for cardiopulmonary bypass.
  • To evaluate the pump's ability to generate physiologic pulsatility and its preload responsiveness.
  • To assess the pump's performance regarding hemolysis and potential clinical applications.

Main Methods:

  • The study presents a new externally valved pulsatile pump.

Related Experiment Videos

  • The pump's pulsatility characteristics (rate-dependent ejection time) and preload responsiveness were evaluated.
  • Hemolysis levels were compared to traditional roller pumps in laboratory studies.
  • Potential clinical applications were explored theoretically.

    • Main Results:

    • The novel pump produces physiologic pulsatility with human-like ejection times.
    • The pump is preload-responsive, adjusting rate and output with filling pressure.
    • Laboratory studies demonstrated significantly less hemolysis compared to roller pumps.
    • The pump is compatible with membrane oxygenators and shows promise for various applications.

    Conclusions:

    • The presented pulsatile pump addresses the need for a satisfactory device in cardiopulmonary bypass.
    • It offers reduced hemolysis and physiologic pulsatility, potentially mitigating procedure-related morbidity.
    • The pump demonstrates broad clinical potential, including ventricular assist, ECMO, and pulsatile hemodialysis.