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Updated: Apr 28, 2026
Isolation, Characterization and Functional Examination of the Gingival Immune Cell Network
Published on: February 16, 2016
Histopathologic and histomorphometric studies and determination of IL-8 in patients with periodontal disease
Myriam A Koss1, Cecilia E Castro2, Silvia Carino3
1Department of Biochemistry, School of Dentistry, National University of Tucumán, Argentina.
Background:
Periodontitis is an inflammatory disease characterized by connective tissue breakdown and alveolar bone resorption.
Objective:
The aim of this study was to make a quantitative evaluation of the gingival tissue components in biopsies from patients with different clinical states of periodontal disease and to determine the relationship between the presence of interleukin-8 and the tissue destruction.
Materials And Methods:
The study group consisted of 33 biopsies from adult subjects. A total of 25 periodontal patients were sub-classified on the basis of the clinical and radiographic criteria in mild, moderate and advanced periodontitis. Gingival samples were obtained from patients in the course of basic periodontal surgeries as a muco-periostic collate. Data were analyzed by the SPSS system.
Results:
Collagen fibres decreased as non-specific chronic states increased. A lymphocyte inflammatory infiltrate changed to a lymphoplasmocytary form. Reactivity to interleukin-8 was detected with the severity of the histopathologic diagnoses; however there was no association with the clinical diagnoses.
Conclusions:
Histopathology and histomorphometry of gingival tissue changed with the degree of inflammation. No evidence of interleukin-8 as a biomarker for clinical diagnoses of periodontitis was obtained.
