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[Acute cystourethritis during pregnancy].

E Calderón Jaimes, J L Arredondo Garcia, J Olvera Salinas

    Ginecologia Y Obstetricia De Mexico
    |March 1, 1989
    PubMed
    Summary

    Nitrofurantoin and ampicillin are safe and effective treatments for acute uncomplicated urinary tract infections in pregnant women. Both antibiotics demonstrated high cure rates, with no significant differences observed between the two regimens.

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    Area of Science:

    • Obstetrics and Gynecology
    • Infectious Diseases
    • Pharmacology

    Background:

    • Acute uncomplicated urinary tract infections (UTIs) are common in pregnancy.
    • Symptomatic UTIs in pregnancy are associated with low-count bacteriuria.
    • Cystourethritis incidence is approximately 12%, predominantly in the first trimester.

    Purpose of the Study:

    • To evaluate the safety and efficacy of multiple-dose nitrofurantoin versus ampicillin for acute uncomplicated UTIs in pregnant women.
    • To compare cure rates and potential adverse outcomes between the two treatment groups.

    Main Methods:

    • A prospective study involving 103 symptomatic pregnant women with confirmed UTIs.
    • Randomized grouping to receive either oral nitrofurantoin (100 mg t.i.d.) or ampicillin (500 mg t.i.d.) for five days.

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  • Follow-up assessments to determine treatment outcomes and complications.

    • Main Results:

    • Overall cure rates ranged from 87% to 89% for both nitrofurantoin and ampicillin.
    • Escherichia coli was the most common pathogen, identified in 67% of infections.
    • No significant differences in efficacy were observed between the two antibiotic regimens.

    Conclusions:

    • Both nitrofurantoin and ampicillin are safe and effective options for treating acute uncomplicated UTIs in pregnant patients.
    • The study supports the use of these antibiotics in obstetric patients with symptomatic lower UTIs.
    • Monitoring for complications like pyelonephritis remains important during pregnancy.