Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment01:08

Effect of Hepatic Disease on Pharmacokinetics: Dose Adjustments Due to Hepatic Impairment

379
Hepatic impairment, characterized by decreased liver function, does not uniformly mandate adjustments in drug dosage. Whether dosage modifications are necessary depends on various factors related to the drug's metabolism and elimination pathways. If a drug is primarily excreted via the kidneys and bypasses significant hepatic processing, if it undergoes minimal metabolic transformation in the liver, or if it is volatile and primarily expelled through the lungs, dose adjustments may not be...
379
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug01:14

Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug

357
In pharmacotherapy, monitoring drug concentrations is paramount, especially for drugs whose therapeutic effects hinge on both the active compound and its metabolite. Hepatic impairment profoundly influences drug potency by altering liver function. If the drug is more potent than its metabolite, impaired liver function amplifies drug activity due to elevated drug concentration levels. Conversely, if the metabolite holds greater potency, diminished liver function diminishes drug activity by...
357
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

271
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
271
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

382
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
382
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

392
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
392
Barriers to Effective Communication II01:21

Barriers to Effective Communication II

5.0K
The barriers to effective communication also include cultural barriers, semantic barriers, gender barriers, and time constraints.
Cultural barriers:
Differences in values, beliefs, religion, knowledge, and tradition can significantly impact communication. Awareness of nonverbal cues is critical, especially when conversing with a patient from a different culture. What appears appropriate in one culture may be inappropriate in another.
Semantic barriers:
As a result of their tendency to use...
5.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Editorial Commentary.

Urology practice·2024
Same author

Editorial Commentary.

Urology practice·2024
Same author

The 4 Questions to Ask and Answer Regarding ICD-10: Second of a 2-Part Series.

Urology practice·2023
Same author

Online Reputation Management for Urologists.

Urology practice·2023
Same author

The 4 Questions to Ask and Answer Regarding ICD-10: First of a 2-Part Series.

Urology practice·2023
Same author

Patient Centered Medical Home: What May Be on the Horizon for Urologists.

Urology practice·2023
Same journal

Chronic Multiorgan Rare Disease: The Role of the Nurse Practitioner as a Leader of the Healthcare Team.

The Journal of medical practice management : MPM·2019
Same journal

The Top Ten Questions on Vendor Negotiations.

The Journal of medical practice management : MPM·2018
Same journal

The Life of a Salmon Examined: What the Healthcare Profession Can Learn from Fish.

The Journal of medical practice management : MPM·2018
Same journal

Ransomware in Hospitals: What Providers Will Inevitably Face When Attacked.

The Journal of medical practice management : MPM·2018
Same journal

Ketogenic Weight Loss: The Lowering of Insulin Levels Is the Sleeping Giant in Patient Care.

The Journal of medical practice management : MPM·2018
Same journal

Unscrewing the Light Bulb: Addressing Systematic Mistreatment of Physicians.

The Journal of medical practice management : MPM·2018
See all related articles

Related Experiment Video

Updated: Apr 28, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
04:22

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

1.4K

Impaired physicians.

Tom Harbin, Neil Baum

    The Journal of Medical Practice Management : MPM
    |May 31, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Physician impairment due to substance abuse is a common challenge. This article offers strategies for effectively managing and reintegrating these doctors into healthcare teams.

    More Related Videos

    Using Retinal Imaging to Study Dementia
    09:17

    Using Retinal Imaging to Study Dementia

    Published on: November 6, 2017

    21.1K
    Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
    02:28

    Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

    Published on: March 1, 2024

    1.1K

    Related Experiment Videos

    Last Updated: Apr 28, 2026

    Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
    04:22

    Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

    Published on: May 30, 2025

    1.4K
    Using Retinal Imaging to Study Dementia
    09:17

    Using Retinal Imaging to Study Dementia

    Published on: November 6, 2017

    21.1K
    Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
    02:28

    Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

    Published on: March 1, 2024

    1.1K

    Area of Science:

    • Medical Practice Management
    • Physician Well-being
    • Substance Abuse in Healthcare

    Background:

    • Healthcare settings frequently encounter physicians whose performance is compromised.
    • Physician impairment, often stemming from drug or alcohol abuse, presents significant management challenges.
    • Addressing these issues is crucial for maintaining patient safety and team cohesion.

    Purpose of the Study:

    • To provide guidance on identifying and interacting with impaired physicians.
    • To offer strategies for supporting physicians with substance abuse issues.
    • To facilitate the reintegration of impaired physicians as valuable team members.

    Main Methods:

    • Literature review on physician impairment and recovery programs.
    • Analysis of best practices in managing difficult physician behaviors.
    • Case study examples of successful interventions.

    Main Results:

    • Impaired physicians require specific, supportive management approaches.
    • Early intervention and clear communication are key to successful outcomes.
    • Reintegration into practice can be achieved with structured support systems.

    Conclusions:

    • Effective management of impaired physicians benefits the individual, the team, and patient care.
    • Proactive strategies are essential for addressing physician impairment in medical environments.
    • Supporting physician recovery fosters a healthier and more productive healthcare system.