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Long-chain acyl coenzyme A synthetase activity during the postnatal development of the mouse brain
1Lions Eye Research Laboratories, LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans, LA 70112, U.S.A.
Abstract:
Palmitic, linoleic, arachidonic, and docosahexaenoic acids were used as substrates to study fatty acid activation in the mouse brain and liver during postnatal development. Long-chain acyl coenzyme A synthetase showed peak activity during the period of rapid oligodendroglial proliferation and myelination. In brain, activation of linoleic and arachidonic acids was highest, followed by palmitic and docosahexaenoic acids. In liver, no appreciable change in enzyme activity was seen during the period of development studied. Palmitic and arachidonic acids showed the highest rate of activation, followed by docosahexaenoic acid. These ontogenic data suggest the presence of a single long-chain acyl coenzyme A synthetase in brain.
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