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Rat brain glycosyltransferase activities during postnatal development.

P Broquet1, M Serres-Guillaumond, H Baubichon-Cortay

  • 1Department of General and Medical Biochemistry, University of Lyon, INSERM U.189 and ERA-CNRS 562, Lyon-Sud Medical School. B.P.12, 69921-Oullins Cedex, France.

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
|May 31, 2014
PubMed
Summary

Glycosyltransferase activity in developing rat brains shows distinct peaks, particularly around post-puberty. This suggests sexual hormones may control these key enzymes involved in brain development.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Developmental Biology

Background:

  • Glycosyltransferases are crucial enzymes for synthesizing glycoproteins and glycolipids.
  • Understanding their developmental regulation is key to comprehending brain maturation.

Purpose of the Study:

  • To investigate the postnatal developmental changes in the enzymatic activity of seven key glycosyltransferases in the rat brain.
  • To identify specific patterns and potential regulatory mechanisms controlling these enzymes during development.

Main Methods:

  • Microsomal fractions from rat brains were analyzed at various postnatal ages (3-42 days).
  • Enzymatic activity assays were performed for glycoprotein and glycolipid glycosyltransferases.

Main Results:

  • Specific temporal activity patterns were observed for different glycosyltransferases.
  • A peak in glycoprotein galactosyltransferase activity occurred at 7 days post partum.
  • Galactosylceramide biosynthesis peaked at 21 days, correlating with myelin synthesis.
  • Six enzymes consistently showed maximal activity between 35-40 days post partum, coinciding with post-puberty.

Conclusions:

  • Rat brain glycosyltransferase activity exhibits dynamic changes during postnatal development.
  • The late peak in activity suggests a potential role for sexual hormones in regulating these enzymes during the post-pubertal period.
  • Further research is warranted to explore the endocrinoneuronal control of glycosyltransferases.