Related Experiment Video
Updated: Apr 28, 2026
Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions
Published on: April 18, 2015
Resource utilisation associated with single digit Dupuytren's contracture treated with either surgery or injection of
Bo Povlsen1, Adrian M Shields, Gev S Bhabra
1Department of Orthopaedic Surgery, Guy's & St. Thomas' Hospital NHS Trust, London, SE1 9RT, UK.
Unlabelled:
The gold standard treatment for Dupuytren's contracture is surgical excision of the cord. A non-surgical treatment with collagenase clostridium histolyticum injection is available but appears costly.
Objectives:
To provide data on resource consumption related to surgical and non-surgical treatment for Dupuytren's contracture.
Design And Participants:
Twenty patients with a single digit Dupuytren's contracture, 10 treated with surgical excision, and 10 treated with a single injection of collagenase.
Measurements:
Minutes spent in theatre, number of follow-up appointments, time to skin healing, and patients return to normal activities of daily living.
Results:
The injection group was significantly better regarding theatre time (p < 0.0001), follow-up appointments (p = 0.048), skin healing time (p < 0.001), and return to normal activities of daily living (p = 0.02) than the operated group.
Conclusions:
There are significant personal and health economic differences between the two methods of treatment which may influence local choice.
