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Updated: Apr 28, 2026
Preparation of Newborn Rat Brain Tissue for Ultrastructural Morphometric Analysis of Synaptic Vesicle Distribution at Nerve Terminals
Published on: June 7, 2019
The arachnoid granulations of the newborn human: An ultrastructural study
D G Gomez1, J E Ehrmann1, D Gordon Potts1
1Department of Radiology and William H. Harkness Research Building, Cornell University Medical College, New York, NY 10021 U.S.A.; Department of Pathology, Division of Health Sciences, Universidad del Valle, Cali, Colombia.
Abstract:
Portions of the superior sagittal sinus and lacunae laterales containing arachnoid villi and granulations from 8 full-term newborn babies were studied by transmission electron microscopy. Arachnoid proliferations from 3 subjects were distended and fixed in vitro by applying a differential pressure of 8 cm H2O to the subarachnoid aspect of the tissues. The remaining cases were fixed in a collapsed state. Distended arachnoid proliferations showed morphologic characteristics associated with similar functional structures in experimental animals: shortened and enlarged interendothelial spaces; micropinocytotic activity and a system of endothelial-lined tubules. All this is taken as evidence that arachnoid proliferations in newborn babies could already be engaged in cerebrospinal fluid absorption.
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