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Updated: Apr 28, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Warfarin-associated intracerebral hemorrhage after ischemic stroke
Signild Åsberg1, Marie Eriksson2, Karin M Henriksson2
1From the Department of Medical Sciences, Uppsala University, Uppsala, Sweden (S.Å., K.M.H., A.T.); Department of Statistics, Umeå University, Umeå, Sweden (M.E.); and AstraZeneca R&D, Mölndal, Sweden (K.M.H.). signild.asberg@medsci.uu.se.
Background And Purpose:
The aim was to investigate the risk of intracerebral hemorrhage (ICH) in patients with ischemic stroke taking warfarin and whether this risk changed over time.
Methods:
Between 2001 and 2008, the Swedish Stroke Register registered 12,790 patients with ischemic stroke discharged on warfarin. The patients was studied in two 4-year periods (inclusion 2001-2004: follow-up until 2005 and inclusion 2005-2008: follow-up until 2009) for which rates of subsequent ICH were calculated. Adjusted hazard ratios, comparing the second period with the first period, were estimated in Cox regression models.
Results:
Of 6039 patients, 58 patients (1.0%) in the first period and 69 of 6751 patients (1.0%) in the second period had subsequent ICH. Annual rates of ICH ranged from 0.37% in the first period to 0.39% in the second period (adjusted hazard ratio, 1.04; 95% confidence interval, 0.73-1.48).
Conclusions:
In this nationwide study, the risk of warfarin-associated ICH among ischemic stroke patients was low and did not change during the 2000s.
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