Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Heart transplantation: update.

C Cabrol1, I Gandjbakhch, A Pavie

  • 1Department of Cardiovascular Surgery, Hopital De La Pitie, Paris, France.

Clinical Transplants
|January 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Who gets a second heart? A current picture of cardiac retransplantation.

Transplantation proceedings·2014
Same author

Bridge to transplantation using paracorporeal biventricular assist devices or the syncardia temporary total artificial heart: is there a difference?

The Journal of cardiovascular surgery·2014
Same author

Early primary cardiac graft failure and combined heart-liver transplantation: need for an uncommon double bypass.

British journal of anaesthesia·2011
Same author

Perioperative management of combined heart-liver transplantation in patients with cirrhosis, renal insufficiency, or pulmonary hypertension.

Clinical transplantation·2010
Same author

[Annuloplasty reduces the mitral leaflets mobility].

Archives des maladies du coeur et des vaisseaux·2008
Same author

Endovascular treatment of descending aortic dissection (type B): short- and medium-term results.

Archives of cardiovascular diseases·2008
Same journal

Clinical Relevance of Donor-Specific IgM Antibodies in HLA Incompatible Renal Transplantation: A Retrospective Single-Center Study.

Clinical transplants·2017
Same journal

Influenza Immunization and the Generation of Anti-HLA and Anti-MICA Antibodies in Patients with Renal Failure and in Kidney Transplant Recipients.

Clinical transplants·2017
Same journal

From Accurate Assessment of Anti-HLA Antibody MFI to Complement-Binding Assays.

Clinical transplants·2017
Same journal

Post-transplant Desensitization for Deceased Donor Kidney Transplant Recipients: A Single Center Experience.

Clinical transplants·2017
Same journal

Acute Rejection in 6-Antigen HLA-Matched Kidney Transplant Recipients: Risk Factors and Outcomes from the Wisconsin Allograft Recipient Database (WisARD).

Clinical transplants·2017
Same journal

C1q Donor-Specific Antibody Associates with Post-transplant Biopsy Findings in Highly- Sensitized Kidney Transplant Recipients.

Clinical transplants·2017
See all related articles

Heart transplantation has over 20 years of success, with 70% survival at 7 years. Advances in immunosuppression improve outcomes, but late graft arteriosclerosis remains a challenge.

Area of Science:

  • Cardiology
  • Immunology
  • Transplant Surgery

Background:

  • Heart transplantation has evolved significantly over two decades.
  • Initial outcomes for the first 8,000 patients demonstrate a 70% 7-year survival rate.
  • Transplantation criteria have broadened, now including diabetic patients and those over 60.

Purpose of the Study:

  • To review the clinical progress and outcomes of heart transplantation.
  • To highlight advancements in immunosuppressive therapies.
  • To identify persistent challenges in long-term graft survival.

Main Methods:

  • Analysis of data from the first 8,000 heart transplant recipients.
  • Review of current immunosuppressive protocols, including OKT3 monoclonal antibody.

Related Experiment Videos

  • Evaluation of strategies to manage late graft complications.

    • Main Results:

    • Achieved a 70% survival rate at 7 years post-transplantation.
    • Expanded indications for heart transplantation.
    • Immunosuppression with OKT3, conventional drugs, and cyclosporine reduces rejection and infection.
    • Late graft arteriosclerosis persists as a significant long-term issue.

    Conclusions:

    • Heart transplantation is a well-established procedure with impressive survival rates.
    • Ongoing improvements in immunosuppression are crucial.
    • Addressing late graft arteriosclerosis is essential for enhancing long-term transplant success.