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Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
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Type 2 Innate Lymphoid Cells in Allergic Disease
Sean Lund1, Hannah H Walford2, Taylor A Doherty1
1Department of Medicine, University of California, La Jolla, CA, USA.
Current Immunology Reviews
|May 31, 2014
Summary
Type II innate lymphoid cells (ILC2) are key players in allergic inflammation, producing Th2 cytokines. Targeting ILC2 offers a promising therapeutic strategy for allergic diseases.
Area of Science:
- Immunology
- Allergy Research
Background:
- Type II innate lymphoid cells (ILC2) are newly identified immune cells.
- ILC2 are found in human tissues like the respiratory tract, gut, and skin.
- Mouse models indicate ILC2's role in allergic conditions such as asthma and atopic dermatitis.
Purpose of the Study:
- To review the development, markers, cytokine production, and regulation of ILC2.
- To focus on the involvement of ILC2 in common allergic diseases.
- To highlight the potential of targeting ILC2 therapeutically.
Main Methods:
- Literature review of existing studies on ILC2.
- Analysis of ILC2 function in allergic inflammation models.
- Summary of upstream regulators and cellular interactions.
Main Results:
- ILC2 produce significant levels of IL-5 and IL-13 (Th2 cytokines).
- Epithelial cytokines (IL-25, IL-33, TSLP) and leukotriene D4 activate ILC2.
- Multiple pathways in allergic diseases converge on ILC2 stimulation.
Conclusions:
- ILC2 are crucial mediators of allergic inflammation.
- Further research is needed to understand ILC2 regulation by other cells.
- Targeting ILC2 presents a potential therapeutic avenue for allergic diseases.
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