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Lipid and protein oxidation in newborn infants after lutein administration

S Perrone1, M Tei1, M Longini1

  • 1Neonatal Care Unit, Department of Molecular and Developmental Medicine, University Hospital of Siena, Viale M. Bracci 16, 53100 Siena, Italy.

Oxidative Medicine and Cellular Longevity
|May 31, 2014
PubMed

Insights

Neonatal lutein supplementation in the first hours of life significantly boosts antioxidant potential and reduces oxidative stress in newborns. This early intervention helps mitigate free radical damage in the immediate postpartum period.

Area of Science:

  • Neonatal health
  • Nutritional science
  • Biochemistry

Background:

  • Oxidative stress (OS) is a significant concern in newborns during the immediate postpartum period.
  • Lutein, a potent antioxidant, has potential benefits in mitigating OS.

Purpose of the Study:

  • To evaluate the efficacy of early neonatal lutein supplementation in reducing oxidative stress.
  • To test the hypothesis that lutein administration in the first hours of life impacts neonatal OS markers.

Main Methods:

  • A randomized controlled, double-blinded trial involving 150 newborns.
  • Supplementation with lutein on the first day postpartum versus no supplementation.
  • Measurement of Total Hydroperoxide (TH), Advanced Oxidation Protein Products (AOPP), and Biological Antioxidant Potential (BAP) in blood samples.

Main Results:

  • The lutein-supplemented group showed a significantly higher increase in BAP compared to controls.
  • The supplemented group exhibited a significantly lower increase in TH, indicating reduced oxidative damage.
  • Lutein supplementation demonstrated a positive impact on antioxidant markers in neonates.

Conclusions:

  • Neonatal lutein supplementation in the early hours of life is effective in increasing antioxidant potential (BAP).
  • Lutein supplementation significantly reduces markers of oxidative stress (TH) in newborns.
  • Early lutein administration can reduce free radical-induced damage at birth.
Abstract

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