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Quantitative high-resolution renal perfusion imaging using 3-dimensional through-time radial generalized
Katherine L Wright1, Yong Chen, Haris Saybasili
1From the Departments of *Biomedical Engineering, †Radiology, Case Western Reserve University, Cleveland, OH; and ‡Siemens Healthcare USA, Inc, Chicago, IL.
Investigative Radiology
|June 1, 2014
Summary
This study presents a free-breathing, high-resolution 3D renal Dynamic Contrast-Enhanced MRI (DCE-MRI) technique. It enables accurate quantitative mapping of kidney perfusion and filtration parameters using accelerated imaging and advanced reconstruction methods.
Area of Science:
- Medical Imaging
- Renal Physiology
- Magnetic Resonance Imaging
Background:
- Dynamic Contrast-Enhanced (DCE) MRI provides quantitative renal perfusion and filtration data.
- Respiratory motion and high spatiotemporal resolution requirements challenge current DCE-MRI implementations.
- Gadolinium contrast agent doses impact examination feasibility.
Purpose of the Study:
- To develop and evaluate a free-breathing, quantitative renal DCE-MRI technique.
- To achieve high spatiotemporal resolution and 3D coverage with reduced contrast doses.
- To enable accurate assessment of renal perfusion and filtration.
Main Methods:
- Utilized a highly accelerated stack-of-stars trajectory with 12.6x undersampling.
- Employed 3D through-time radial generalized autocalibrating partially parallel acquisition (GRAPPA) for image reconstruction.
- Compensated for respiratory motion using a novel registration algorithm and performed pharmacokinetic analysis.
Main Results:
- Successfully reconstructed high-resolution 3D DCE-MRI data with high temporal (2.1-2.9s) and spatial (2.2mm) resolution.
- Achieved accurate quantitative estimates of renal perfusion and filtration parameters using half and quarter doses of gadolinium contrast.
- Generated 3D pixelwise parameter maps for detailed functional analysis.
Conclusions:
- A free-breathing, highly accelerated 3D renal DCE-MRI technique was successfully developed.
- 3D through-time radial GRAPPA enables high-resolution reconstruction from undersampled data.
- This method allows for accurate, quantitative 3D mapping of renal perfusion and filtration without breath-holding.
