Related Experiment Video

Updated: Apr 28, 2026

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma
09:52

Isolated Hepatic Perfusion as a Treatment for Liver Metastases of Uveal Melanoma

Published on: January 25, 2015

12.8K

Treatments for noncutaneous melanoma

Danny N Khalil1, Richard D Carvajal2

  • 1Department of Medicine, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Hematology/Oncology Clinics of North America
|June 2, 2014
PubMed

Insights

Treating advanced noncutaneous melanoma is improving due to genetic insights. Understanding unique melanoma subtypes and their driving genetic alterations enables effective treatment strategies for this previously intractable disease.

Area of Science:

  • Oncology
  • Genetics
  • Dermatology

Background:

  • Historically, noncutaneous melanoma treatment mirrored cutaneous melanoma approaches, especially in metastatic cases.
  • Advances in genetic tools have revealed the distinct biology of noncutaneous melanomas.
  • This has led to a better understanding of melanoma subtypes and their specific genetic drivers.

Purpose of the Study:

  • To highlight the shift in treating noncutaneous melanoma.
  • To emphasize the role of genetic characterization in advancing treatment.
  • To show how understanding unique melanoma biology improves outcomes.

Main Methods:

  • Review of historical treatment paradigms for noncutaneous melanoma.
  • Analysis of recent advancements in genetic profiling of melanoma subtypes.
  • Correlation of specific genetic alterations with treatment efficacy.

Main Results:

  • Genetic tools enable precise characterization of noncutaneous melanoma subtypes.
  • Identification of key genetic alterations driving melanoma progression.
  • Demonstration of improved treatment outcomes in advanced noncutaneous melanoma.

Conclusions:

  • The unique biology of noncutaneous melanoma necessitates distinct therapeutic strategies.
  • Genetic insights are crucial for developing effective treatments for advanced noncutaneous melanoma.
  • Melanoma treatment is evolving from intractable to treatable due to personalized genetic approaches.
Keywords:
Anorectal melanomaMucosal melanomaOcular melanomaUveal melanomaVulvovaginal melanoma

More Related Videos

A 3D Organotypic Melanoma Spheroid Skin Model08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

18.1K
Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver09:02

Percutaneous Hepatic Perfusion PHP with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

11.4K

Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.2K
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
2.6K