[Pulmonary metastases - 12-year experience with surgical therapy]

Area of Science:

• Oncology
• Thoracic Surgery
• Cancer Metastasis

Background:

• Radical surgical therapy for selected secondary pulmonary tumors is a proven procedure for extending long-term patient survival.
• This retrospective analysis examines patients who underwent surgery for pulmonary metastases over a 12-year period.

Purpose of the Study:

• To evaluate the efficacy and outcomes of pulmonary metastasectomy for various secondary pulmonary tumors.
• To identify prognostic factors influencing survival and disease-free intervals after surgery.

Main Methods:

• Retrospective analysis of 159 patients undergoing surgery for secondary pulmonary tumors between 2001 and 2012.
• Procedures included unilateral and bilateral surgeries, laser excisions, and radiofrequency ablation.
• Data collected on patient demographics, tumor type, number of metastases, perioperative outcomes, survival, and disease progression.

Main Results:

• Pulmonary metastasectomy demonstrated acceptable perioperative morbidity (13.2%) with zero lethality.
• 56.6% of patients survived post-metastasectomy with a median survival of 44 months; 3-year and 5-year survival rates were 59% and 39%, respectively.
• The number of metastases was a significant prognostic factor; multiple metastases increased the risk of death and disease progression.

Conclusions:

• Pulmonary metastasectomy plays a positive role in the treatment of disseminated tumors.
• The number of metastases is a critical prognostic factor for both long-term survival and disease-free intervals (DFI) in patients undergoing metastasectomy.