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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor
Published on: February 16, 2018
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A versatile electrochemical sensing receptor based on a molecularly imprinted polymer
Dutduan Udomsap1, Catherine Branger, Gérald Culioli
1Université de Toulon, MAPIEM, EA 4323, 83957 La Garde, France. branger@univ-tln.fr brisset@univ-tln.fr.
Summary
Researchers developed novel electrochemical molecularly imprinted polymers (e-MIPs) for analyte detection. This method uses a redox tracer signal for simple and effective benzo[a]pyrene determination.
Area of Science:
- Electrochemistry
- Polymer Science
- Analytical Chemistry
Background:
- Molecularly imprinted polymers (MIPs) are synthetic receptors with high selectivity.
- Electrochemical detection offers sensitivity and simplicity.
- Integrating these fields can lead to novel sensing platforms.
Purpose of the Study:
- To report the first development of electrochemical molecularly imprinted polymers (e-MIPs).
- To establish a method for analyte determination using e-MIPs.
- To demonstrate the utility of a redox tracer for signal generation.
Main Methods:
- Synthesis of cross-linked MIPs incorporating a redox tracer (vinylferrocene) within binding cavities.
- Electrochemical determination of the redox tracer signal.
- Analysis of benzo[a]pyrene as the target analyte.
Main Results:
- Successful fabrication of e-MIPs.
- A direct correlation between the redox tracer signal and analyte presence.
- Simple and effective determination of benzo[a]pyrene.
Conclusions:
- Electrochemical molecularly imprinted polymers (e-MIPs) represent a new class of sensors.
- The incorporation of a redox tracer simplifies analyte detection.
- This approach offers a promising route for sensitive and selective electrochemical sensing.

