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Related Experiment Videos

Cannabis use and first manic episode.

Nathalie Bally1, Daniele Zullino1, Jean-Michel Aubry2

  • 1Division of Addiction Psychiatry, Department of Mental Health and Psychiatry, Geneva University Hospitals, Switzerland.

Journal of Affective Disorders
|June 3, 2014
PubMed
Summary

Cannabis use is common in bipolar disorder patients and may precede manic episodes. However, more research is needed to confirm a causal link between cannabis and the onset of mania.

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Addiction Medicine

Background:

  • Cannabis is frequently abused by individuals with bipolar disorder.
  • Increased cannabis use correlates with a higher risk of psychotic disorders.

Purpose of the Study:

  • To review existing literature on the association between cannabis use and the onset of mania in bipolar disorder patients.

Main Methods:

  • A systematic literature search was conducted on Medline and PsychInfo for articles published between 1972 and 2013.
  • Keywords included "first manic episode," "onset mania," and "bipolar disorder and cannabis."
  • References from relevant papers were also reviewed.

Main Results:

  • Lifetime cannabis use is reported in approximately 70% of bipolar patients, with 30% experiencing abuse or dependence.
Keywords:
Bipolar disordersCannabisMarijuanaOnset mania

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  • Cannabis use is linked to earlier onset of mania and potentially more frequent mood episodes, though findings are inconsistent.
  • While cannabis use often precedes the first manic episode, a definitive causal relationship remains undetermined.

    • Conclusions:

    • The relationship between cannabis use and the onset of mania requires further investigation.
    • Limitations include varying definitions of cannabis use and a lack of controlled studies.
    • Clarifying the causal link is essential for effective treatment strategies.