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A fluorescent probe for imaging symmetric and asymmetric cell division in neurosphere formation
Seong-Wook Yun1, Cheryl Leong, Xuezhi Bi
1Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore.
Chemical Communications (Cambridge, England)
|June 3, 2014
Abstract:
We report here a novel fluorescent chemical probe which stains distinct neural stem/progenitor cells (NSPCs) by binding to acid ceramidase in mouse neurospheres. is distributed evenly or unevenly to the daughter cells during multiple mitoses enabling the live imaging of symmetric and asymmetric divisions of isolated NSPCs.
