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Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
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Analysis of Cell Migration within a Three-dimensional Collagen Matrix
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Interplay between intercellular signaling and cell movement in development.

Koichiro Uriu1, Luis G Morelli2, Andrew C Oates3

  • 1Theoretical Biology Laboratory, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

Seminars in Cell & Developmental Biology
|June 3, 2014
PubMed
Summary
This summary is machine-generated.

Intercellular signaling guides collective cell movement in animal development. Cell movement also impacts signaling by altering cell arrangements, highlighting their crucial interplay in morphogenesis.

Keywords:
Cell movementConvergent extensionIntercellular signalingNeural crest migrationSegmentation clockVertebrate axis elongation

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Area of Science:

  • Developmental Biology
  • Cell Biology
  • Theoretical Biology

Background:

  • Cell movement and intercellular signaling are fundamental to morphogenesis.
  • Intercellular signaling directs collective cell migration through cell-cell contact.
  • Cell movement can modify local signaling by rearranging cells.

Purpose of the Study:

  • To discuss theoretical models of intercellular signaling regulating collective cell movement.
  • To review theoretical studies on how cell movement influences intercellular signaling.
  • To emphasize the importance of their interplay in embryonic development.

Main Methods:

  • Review of theoretical models on signaling-driven cell movement.
  • Analysis of theoretical studies on movement-influenced signaling.
  • Case studies including neural crest migration, convergent extension, and zebrafish segmentation clock.

Main Results:

  • Theoretical models demonstrate signaling's role in directing collective cell migration.
  • Studies show cell movement can alter signaling pathways.
  • The interdependence of cell movement and signaling is evident in various developmental processes.

Conclusions:

  • The interplay between cell movement and intercellular signaling is critical for understanding morphogenesis.
  • Considering both factors is essential for accurate modeling of embryonic development.
  • Future research should integrate these coupled dynamics.