Related Experiment Video

Updated: Apr 28, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

4.9K

Increased serum C1q-binding adiponectin complex to total-adiponectin ratio in men with multi-vessel coronary disease

Ken Kishida1, Yasuhiko Nakagawa2, Hironori Kobayashi3

  • 1Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan ; Kishida Clinic, Toyonaka, Osaka, Japan.

Diabetology & Metabolic Syndrome
|June 3, 2014
PubMed

Insights

The ratio of C1q-binding adiponectin to total adiponectin (C1q-APN/Total-APN) increases with the number of diseased coronary vessels in men. This finding suggests C1q-APN may be a useful biomarker for coronary artery disease severity.

Area of Science:

  • Cardiovascular Research
  • Biochemistry
  • Immunology

Background:

  • Adiponectin is recognized for its role in stabilizing atherosclerotic plaques.
  • Previous research linked total adiponectin (Total-APN) levels to coronary artery disease (CAD) severity in men.
  • A novel finding indicated adiponectin binds to C1q in human blood, with C1q-binding adiponectin (C1q-APN)/Total-APN ratios associated with CAD in type 2 diabetes.

Purpose of the Study:

  • To investigate the relationship between circulating C1q-APN levels and the number of angiographically defined coronary artery vessels in male subjects.
  • To determine if C1q-APN levels correlate with the extent of coronary artery disease.
  • To explore the potential of C1q-APN as a biomarker for CAD.

Main Methods:

  • The study included 53 male Japanese patients undergoing diagnostic coronary angiography.
  • Enzyme-linked immunosorbent assays were used to measure serum levels of Total-APN, high-molecular weight adiponectin (HMW-APN), C1q-APN, and C1q.

Main Results:

  • A significant trend of increasing serum C1q-APN/Total-APN ratio was observed with increasing numbers of diseased coronary vessels (single and multi-vessel disease).
  • No significant correlation was found between serum Total-APN, HMW-APN, C1q-APN, or C1q levels and the number of diseased coronary vessels.

Conclusions:

  • The serum C1q-APN/Total-APN ratio progressively increases in men with single and multi-vessel coronary artery disease.
  • This suggests that the C1q-APN/Total-APN ratio may serve as a valuable indicator of coronary artery disease severity.
Abstract

Keywords:
AdiponectinAngiographic coronary vesselC1qC1q-binding adiponectinCoronary artery disease

More Related Videos

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay10:12

A Sensitive and Specific Quantitation Method for Determination of Serum Cardiac Myosin Binding Protein-C by Electrochemiluminescence Immunoassay

Published on: August 8, 2013

16.1K

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
1.8K
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
889
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
971
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
726
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
751
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
1.1K