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Updated: Apr 28, 2026

In vivo 19F MRI for Cell Tracking
Published on: November 25, 2013
A superfluorinated molecular probe for highly sensitive in vivo(19)F-MRI
Ilaria Tirotta1, Alfonso Mastropietro, Chiara Cordiglieri
1Laboratory of Nanostructured Fluorinated Materials (NFMLab), Department of Chemistry, Materials, and Chemical Engineering "Giulio Natta", ‡Fondazione Centro Europeo Nanomedicina, and ∥Department of Electronics, Information, and Bioengineering, Politecnico di Milano , Milan, Italy.
Abstract:
(19)F-MRI offers unique opportunities to image diseases and track cells and therapeutic agents in vivo. Herein we report a superfluorinated molecular probe, herein called PERFECTA, possessing excellent cellular compatibility, and whose spectral properties, relaxation times, and sensitivity are promising for in vivo (19)F-MRI applications. The molecule, which bears 36 equivalent (19)F atoms and shows a single intense resonance peak, is easily synthesized via a simple one-step reaction and is formulated in water with high stability using trivial reagents and methods.
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