Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Protein Networks

Protein Networks

Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...

Protein-Protein Interfaces

Protein-Protein Interfaces

Protein Complexes with Interchangeable Parts

Protein Complexes with Interchangeable Parts

Protein Complexes with Interchangeable Parts

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A scalable HPC framework for bioinformatics in resource-limited settings: design principles, implementation, and sustainability from the UVRI experience.

Bioinformatics (Oxford, England)·2026

Same author

Uncovering genetic variation in humoral inborn errors of immunity in African populations: insights from the African genome variation database.

Scientific reports·2026

Same author

InterPro: the protein sequence classification resource in 2025.

Nucleic acids research·2024

Same author

The Pfam protein families database: embracing AI/ML.

Nucleic acids research·2024

Same author

The African Human Microbiome Portal: a public web portal of curated metagenomic metadata.

Database : the journal of biological databases and curation·2024

Same author

Performance and accuracy evaluation of reference panels for genotype imputation in sub-Saharan African populations.

Cell genomics·2023

Same journal

Covariance decomposition for distance based species tree estimation.

BMC bioinformatics·2026

Same journal

SNPio: a Python interface for population genomic data processing.

BMC bioinformatics·2026

Same journal

SpaHNR: a spatial domain identification method via sparse attention-based hierarchical node representation and multi-view contrastive learning.

BMC bioinformatics·2026

Same journal

OpenIMC: an open-source platform for analyzing single-cell and spatial proteomics by imaging mass cytometry.

BMC bioinformatics·2026

Same journal

NAP: an open source pipeline for cross-domain microbiome profiling using Nanopore sequencing-derived amplicon data.

BMC bioinformatics·2026

Same journal

SurvGME: an R package for survival analysis with graphical and measurement error models.

BMC bioinformatics·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Apr 28, 2026

Label-Free Immunoprecipitation Mass Spectrometry Workflow for Large-scale Nuclear Interactome Profiling

Label-Free Immunoprecipitation Mass Spectrometry Workflow for Large-scale Nuclear Interactome Profiling

Published on: November 17, 2019

A web-based protein interaction network visualizer.

Gustavo A Salazar¹, Ayton Meintjes, Gaston K Mazandu

¹Computational Biology Group, IDM, Faculty of Health Sciences, University of Cape Town, Anzio Road, Cape Town, South Africa. gustavo@cbio.uct.ac.za.

BMC Bioinformatics

|June 3, 2014

Summary

This summary is machine-generated.

Protein-Protein Interaction Network Visualizer (PINV) is a new web tool for interactive exploration of protein interaction data. This open-source application simplifies visualization and sharing of complex biological networks.

More Related Videos

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

Published on: March 3, 2015

Related Experiment Videos

Last Updated: Apr 28, 2026

Label-Free Immunoprecipitation Mass Spectrometry Workflow for Large-scale Nuclear Interactome Profiling

Label-Free Immunoprecipitation Mass Spectrometry Workflow for Large-scale Nuclear Interactome Profiling

Published on: November 17, 2019

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells

Published on: March 3, 2015

Area of Science:

Bioinformatics
Computational Biology
Systems Biology

Background:

Protein-protein interactions (PPIs) are crucial for cellular functions.
Vast amounts of PPI data exist, necessitating effective visualization tools.
Existing tools lack native web-based interactive exploration capabilities.

Purpose of the Study:

To develop an accessible, web-based tool for interactive visualization of protein interaction networks.
To address the need for a native web application for exploring large-scale PPI data.

Main Methods:

Developed PINV, an open-source, native web application.
Utilized BioJS components and the D3 library for graphic layouts.
Created an interactive platform for visualizing protein interaction data.

Main Results:

PINV offers an attractive, fully interactive visualization of complex protein networks.
The tool enables querying, filtering, and manipulation of network subsets.
Demonstrated PINV's utility with multi-organism interaction networks.

Conclusions:

PINV simplifies the sharing and publishing of research findings.
The open-source nature of PINV fosters collaboration in research environments.
PINV provides an easily accessible forum for visualizing and exploring PPI data.