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Related Concept Videos

Protein Families02:47

Protein Families

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Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
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Protein-protein Interfaces02:04

Protein-protein Interfaces

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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Protein Networks02:26

Protein Networks

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An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
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Protein Organization01:24

Protein Organization

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Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
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Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

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An Integrated Approach for Microprotein Identification and Sequence Analysis
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An Integrated Approach for Microprotein Identification and Sequence Analysis

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InterPro: the protein sequence classification resource in 2025.

Matthias Blum1, Antonina Andreeva1, Laise Cavalcanti Florentino1

  • 1European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton CB10 1SD, UK.

Nucleic Acids Research
|November 20, 2024
PubMed
Summary
This summary is machine-generated.

InterPro, a protein sequence classification resource, now integrates more AlphaFold structures and uses AI for protein family descriptions. This update enhances its utility for biological research and data analysis.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Protein Science

Background:

  • InterPro is a vital resource for classifying protein sequences into families.
  • It integrates predictive models (signatures) from multiple databases.
  • InterPro annotates over 200 million sequences, covering UniProtKB extensively.

Purpose of the Study:

  • To report on the status and recent developments of the InterPro database (version 101.0).
  • To highlight new features in the database, web interface, and software.
  • To showcase advancements in protein family classification and domain prediction.

Main Methods:

  • Integration of predictive models from various member databases.
  • Annotation of protein sequences against InterPro entries.
  • Inclusion of mappings to external resources like Gene Ontology and AlphaFold.

Main Results:

  • InterPro version 101.0 details significant updates and developments.
  • Increased integration of AlphaFold-predicted protein structures.
  • Enhanced protein family descriptions utilizing artificial intelligence.
  • Creation of over 5000 new InterPro entries in the past two years.
  • Access to 85,000 protein families and domains, with archival support for retired databases.

Conclusions:

  • InterPro continues to evolve as a comprehensive resource for protein sequence classification.
  • Recent updates improve the understanding and analysis of protein families and structures.
  • The freely available data, software, and tools support diverse biological research endeavors.