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Low-dose danazol for mastalgia.

P R Maddox1, B J Harrison, R E Mansel

  • 1Department of Surgery, University of Wales College of Medicine, Cardiff, UK.

British Journal of Clinical Practice. Supplement
|November 1, 1989
PubMed
Summary
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Low-dose danazol therapy effectively manages severe cyclical mastalgia with minimal side effects. This approach offers significant symptom relief and improved tolerability for patients compared to conventional danazol dosages.

Area of Science:

  • Gynecology
  • Pharmacology

Background:

  • Cyclical mastalgia is a common condition causing breast pain in women.
  • Conventional danazol dosages provide symptom relief but are associated with significant side effects.
  • Severe and relapsing cases require effective treatment with improved tolerability.

Purpose of the Study:

  • To evaluate the efficacy and safety of a low-dose danazol maintenance therapy for severe cyclical mastalgia.
  • To assess the reduction in side effects associated with a reduced danazol regimen.

Main Methods:

  • A prospective study involving 34 women with severe cyclical mastalgia.
  • Administration of low-dose danazol (mean 800 mg/month) during the luteal phase.
  • Assessment of symptom relief and side effects compared to previous conventional danazol treatment.

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Main Results:

  • Complete symptom relief in 44% of women; substantial improvement in the remainder.
  • Significant reduction in side effects, occurring in only 12% of patients.
  • Side effects were mild and well-tolerated by all participants.

Conclusions:

  • Low-dose danazol maintenance therapy is an effective and well-tolerated treatment for severe cyclical mastalgia.
  • This regimen minimizes side effects commonly seen with conventional danazol dosages.
  • It represents a viable option for women experiencing persistent cyclical breast pain.