Scandium versus yttrium{amino-alkoxy-bis(phenolate)} complexes for the stereoselective ring-opening polymerization of...

Scandium and yttrium amide complexes Ln{ONXO(R1,R2)}(N(SiHMe2)2)(THF)n (Ln = Sc, n = 0 or Y, n = 1; X = NMe2 or OMe; R(1) = Cumyl or p-Cl-Cumyl; R(2) = Me or Cumyl) were prepared by aminolysis of Ln[N(SiHMe2)2]3(THF) with the corresponding tetradentate diamino- or alkoxy-amino-bis(phenol) pro-ligands {ONXO(R1,R2)}H2. In the solid state and in toluene solution, the scandium complexes are monomeric and 5-coordinated, while the analogous yttrium complexes all bear an extra THF-coordinated molecule and are 6-coordinated. Sc{ONXO(R1,R2)}(N(SiHMe2)2) complexes are single-site initiators for the ring-opening polymerization (ROP) of racemic lactide but are less active than their yttrium analogues Y{ONXO(R1,R2)}(N(SiHMe2)2)(THF); also, in contrast to the latter ones, they are inactive in the ROP of the more demanding racemic β-butyrolactone. On the other hand, the scandium amide complexes feature a significantly improved control over the ROP of lactide, yielding PLAs with much narrower molecular weight distributions (Đ(M) < 1.1 for Sc vs. 1.5-2.0 for Y). The yttrium complex with the very bulky o,p-dicumyl-substituted ligand is more heteroselective than its scandium analogue (P(r) = 0.88 vs. 0.83), while the opposite is observed with complexes based on p-methyl-substituted ligands (P(r) = 0.50 in toluene or 0.72-0.75 in THF for Y vs. P(r) = 0.75-0.83 for Sc in toluene). These reactivity and selectivity trends are rationalized by a much more sterically crowded coordination sphere in scandium than in yttrium complexes.