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Updated: Apr 28, 2026
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Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
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[Nasopharyngeal cancers, an overview]
Pauline Jardel1, Juliette Thariat2, Pierre Blanchard3
1CHU de la Milétrie, Service d'oncologie radiothérapique, 2, rue de la Milétrie, 86000 Poitiers, France.
Bulletin Du Cancer
|June 3, 2014
Summary
Nasopharyngeal cancer, rare in France but common in Asia, is treated with intensity-modulated radiotherapy (IMRT) and chemotherapy. This combination improves survival rates and local control for advanced tumors.
Area of Science:
- Oncology
- Radiation Oncology
- Medical Oncology
Context:
- Nasopharyngeal cancer (NPC) is uncommon in France but endemic in Southeast Asia.
- Historically, exclusive radiation therapy yielded local control rates of 50-75% for T3-T4 tumors.
- Intensity-modulated radiotherapy (IMRT) enhances tumor coverage and spares surrounding organs at risk.
Purpose:
- To review the current management of nasopharyngeal cancer.
- To highlight the benefits of IMRT and concurrent chemoradiotherapy.
- To discuss ongoing research into optimizing treatment strategies.
Summary:
- Concurrent chemotherapy with IMRT significantly improves survival, with 5-year overall survival exceeding 75%.
- Platinum-based concurrent radiochemotherapy is standard, with ongoing trials exploring induction and adjuvant chemotherapy to reduce distant failure.
- Follow-up strategies focus on early detection of local recurrence and management of long-term toxicities.
Impact:
- IMRT and concurrent chemoradiotherapy represent the current standard of care for nasopharyngeal cancer.
- Optimizing chemotherapy regimens may further reduce distant failure rates and improve patient outcomes.
- Effective follow-up protocols are crucial for managing recurrence and long-term side effects.
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