Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Metastasis02:30

Metastasis

5.4K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.4K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.3K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.5K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

4.3K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Snapshot division-of-aperture spectropolarimeter and polarization radiometer.

Applied optics·2025
Same author

Short-wave infrared (SWIR) polarization imaging using division-of-focal-plane imaging polarimeter.

Scientific reports·2025
Same author

Microfluidic Flow Promotes a Steatotic Phenotype in Induced Pluripotent Stem Cell-Derived Hepatocytes that is Influenced by Disease State of the Donor.

Gastro hep advances·2025
Same author

Corrigendum: Microfluidic-based human prostate-cancer-on-chip.

Frontiers in bioengineering and biotechnology·2024
Same author

Carboxymethyl Chitosan as a Reversible Template of Calcium Phosphate for Multifunctional Conservation of Carbonate Stone.

ACS applied materials & interfaces·2024
Same author

Correction: AR loss in prostate cancer stroma mediated by NF-κB and p38-MAPK signaling disrupts stromal morphogen production.

Oncogene·2024
Same journal

Systematic Comparison of Droplet-Based and Microwell-Based Platforms for Comprehensive Single-Cell Transcriptomic Analysis in Clinical Samples.

IET nanobiotechnology·2026
Same journal

Mechanistic Insights Into Protein Aggregation Inhibition by Green-Synthesized Silver Nanoparticles: A Study on Human Lysozyme.

IET nanobiotechnology·2026
Same journal

Fabrication, Characterization, and Antifungal Activity of Chitosan-Cyproconazole Nanocomposite for Simultaneous Wheat Stem Rust Control and Growth Enhancement.

IET nanobiotechnology·2026
Same journal

Exploring the Antiviral Potential of Tungsten Oxide Nanoparticles Against Herpes Simplex Virus Type 1: A Promising Alternative to Acyclovir.

IET nanobiotechnology·2026
Same journal

Gum-Assisted Magnesium Oxide Nanoparticles Using Guar Extract Focusing on Their Bioactivities.

IET nanobiotechnology·2026
Same journal

Preparation of Fe<sub>3</sub>O<sub>4</sub>/Chitosan-Acrylic Acid Nanocomposite as an Adsorbent for the Removal of Cu<sup>2+</sup> Ions From Real Water Samples.

IET nanobiotechnology·2025
See all related articles

Related Experiment Video

Updated: Apr 28, 2026

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
05:17

Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

Published on: May 14, 2019

8.2K

Specific interactions between functionalised particles and circulating tumour cells.

Matthew T Stamm, Andrew S Trickey-Glassman, Linan Jiang

    IET Nanobiotechnology
    |June 4, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Targeting cancer cells with antibody-functionalized silica particles shows binding increases with concentration but not always incubation time. Cell-particle interactions can limit binding efficiency.

    More Related Videos

    Capture and Release of Viable Circulating Tumor Cells from Blood
    08:10

    Capture and Release of Viable Circulating Tumor Cells from Blood

    Published on: October 28, 2016

    8.2K
    Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle
    05:49

    Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle

    Published on: April 27, 2021

    2.1K

    Related Experiment Videos

    Last Updated: Apr 28, 2026

    Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment
    05:17

    Micromanipulation of Circulating Tumor Cells for Downstream Molecular Analysis and Metastatic Potential Assessment

    Published on: May 14, 2019

    8.2K
    Capture and Release of Viable Circulating Tumor Cells from Blood
    08:10

    Capture and Release of Viable Circulating Tumor Cells from Blood

    Published on: October 28, 2016

    8.2K
    Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle
    05:49

    Modeling the Effects of Hemodynamic Stress on Circulating Tumor Cells using a Syringe and Needle

    Published on: April 27, 2021

    2.1K

    Area of Science:

    • Biomedical Engineering
    • Nanotechnology
    • Cancer Research

    Background:

    • Receptor-ligand interactions are key for targeted cancer therapy.
    • EpCAM (Epithelial Cell Adhesion Molecule) is a target for breast cancer cell targeting.

    Purpose of the Study:

    • Quantitatively characterize the targeting efficiency of EpCAM-targeted silica nanoparticles.
    • Investigate the impact of incubation time and particle concentration on nanoparticle binding to cancer cells.

    Main Methods:

    • Utilized silica particles functionalized with EpCAM antibodies.
    • Employed EpCAM-expressing BT-20 breast cancer cells for experiments.
    • Experimentally varied incubation time and particle concentration.

    Main Results:

    • Nanoparticle binding increased with particle concentration.
    • Binding did not consistently increase with incubation time.
    • Identified loss of binding affinity due to cell-particle-cell interactions.
    • Observed peak cell-surface coverage at high particle concentrations.

    Conclusions:

    • Cell-particle-cell interactions can limit nanoparticle binding efficiency.
    • Optimal particle concentration is crucial for maximizing cell surface coverage.
    • Particle detachment may negatively impact cellular binding affinity.