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Updated: Apr 28, 2026

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances
Published on: October 11, 2018
Discussion of combining biomarkers to optimize patient treatment recommendations
Ying-Qi Zhao1, Michael R Kosorok2,3
1Department of Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, Wisconsin 53792, U.S.A.
Abstract:
Kang, Janes and Huang propose an interesting boosting method to combine biomarkers for treatment selection. The method requires modeling the treatment effects using markers. We discuss an alternative method, outcome weighted learning. This method sidesteps the need for modeling the outcomes, and thus can be more robust to model misspecification.
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