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[Degradation of polyurethanes in aqueous environment]
Iyo Kizai Kenkyujo Hokoku. Reports of the Institute for Medical and Dental Engineering, Tokyo Medical and Dental University
|January 1, 1989
Summary
This study modeled polyurethane degradation in aqueous environments. In vitro results accurately predicted in vivo polyurethane stability, aiding material selection for medical devices.
Area of Science:
- Polymer science
- Biomaterials science
- Materials degradation
Context:
- Polyurethanes are widely used in medical devices.
- Understanding their degradation is crucial for device longevity and patient safety.
- In vivo degradation studies are complex and time-consuming.
Purpose:
- To establish an in vitro model for predicting polyurethane degradation.
- To evaluate the hydrolytic stability of medical-grade polyurethanes.
- To correlate in vitro degradation findings with in vivo performance.
Summary:
- Four polyurethanes, including diphenylmethane diisocyanate (MDI)-based and hydrogenated MDI (HMDI)-based materials, were exposed to buffered aqueous solutions at 70°C for up to one year.
- Changes in material properties were assessed using Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR), tensile testing, and viscosity measurements.
- Hydrolytic degradation stability increased in the order: HMDI, TM-3, Biomer, and Cardiothane, consistent with in vivo observations.
Impact:
- The developed in vitro model effectively predicts in vivo polyurethane degradation.
- This research aids in selecting polyurethanes with enhanced stability for medical applications.
- Provides a valuable tool for accelerating the development of more durable medical biomaterials.