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Updated: Apr 28, 2026

High-Resolution Three-Dimensional Imaging of the Footpad Vasculature in a Murine Hindlimb Gangrene Model
Published on: March 16, 2022
[Lower limb occlusive arterial disease: Diagnosis problems in 2014]
Joël Constans1, Alessandra Bura-Rivière2
1Hôpital Saint-André, médecine vasculaire, 33075 Bordeaux, France.
Diagnosing peripheral occlusive arterial disease remains challenging. Early detection using ankle-brachial index and toe systolic pressure is vital, especially for critical limb ischemia.
Area of Science:
- Vascular Medicine
- Diagnostic Imaging
- Arterial Diseases
Context:
- Peripheral occlusive arterial disease (POAD) diagnosis presents ongoing challenges.
- Early detection is crucial for effective management and improved patient outcomes.
- Current diagnostic tools require careful selection based on patient comorbidities.
Purpose:
- To review current diagnostic methods for peripheral occlusive arterial disease.
- To highlight the utility of ankle-brachial index and toe systolic pressure measurements.
- To emphasize the importance of objective testing in critical limb ischemia.
Summary:
- Ankle-brachial index is a primary tool for diagnosing POAD.
- Toe systolic pressure is valuable in patients with diabetes or renal failure.
- Treadmill tests and TcPO2 are useful for evaluating walking symptoms and critical ischemia.
- Objective testing, including TcPO2 and toe systolic pressure, is mandatory for critical limb ischemia, as ankle pressure alone is insufficient.
Impact:
- Improved diagnostic accuracy for peripheral occlusive arterial disease.
- Timely identification and management of critical limb ischemia.
- Enhanced patient care through appropriate utilization of diagnostic modalities.
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