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MYC and the control of DNA replication

David Dominguez-Sola1, Jean Gautier2

  • 1Institute for Cancer Genetics, Columbia University, New York, New York 10032.

Cold Spring Harbor Perspectives in Medicine
|June 4, 2014
PubMed
Summary

The MYC oncogene, often overexpressed in cancers, normally regulates DNA replication. Aberrant MYC expression causes replication stress, potentially leading to genomic instability and tumor development.

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