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Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
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Closed-loop optical neural stimulation based on a 32-channel low-noise recording system with online spike sorting
T K T Nguyen1, Z Navratilova, H Cabral
1Imec, 3001 Leuven, Belgium. Department of Electrical Engineering, Katholieke Universiteit Leuven, 3001 Leuven, Belgium.
Journal of Neural Engineering
|June 4, 2014
Summary
This study presents a closed-loop neuro-electronic system for precise neural stimulation. The system integrates optical stimulation with simultaneous electrical recording and analysis for advanced optogenetic research.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Optogenetics
Background:
- Closed-loop neuro-electronic systems are crucial for scientific research and clinical neuroprosthetics.
- Integrating optical stimulation with neural recording enhances stimulation selectivity.
Purpose of the Study:
- To develop a closed-loop system for localized optical stimulation and simultaneous electrical neural activity measurement.
- To enable real-time analysis and feedback for enhanced neural control.
Main Methods:
- Implemented a template matching algorithm for online signal analysis.
- Developed a system for simultaneous 32-channel neural recording, online spike sorting, and classification.
- Utilized recorded neural data to trigger a light-emitting diode (LED) light source via TTL signals.
Main Results:
- Successfully demonstrated closed-loop operation using recorded data in awake rats.
- Achieved online classification of neural activity from 32 channels.
- Enabled triggered optical stimulation based on real-time neural activity detection.
Conclusions:
- The developed system achieves a total processing time of 8 ms.
- This rapid processing is suitable for real-time optogenetic studies of brain mechanisms.
- The system offers a powerful tool for advancing neuroscience research and neuroprosthetic development.
