Related Experiment Video
Updated: Apr 28, 2026
Optrode Array for Simultaneous Optogenetic Modulation and Electrical Neural Recording
Published on: September 1, 2022
Closed-loop optical neural stimulation based on a 32-channel low-noise recording system with online spike sorting
T K T Nguyen1, Z Navratilova, H Cabral
1Imec, 3001 Leuven, Belgium. Department of Electrical Engineering, Katholieke Universiteit Leuven, 3001 Leuven, Belgium.
Objective:
Closed-loop operation of neuro-electronic systems is desirable for both scientific and clinical (neuroprosthesis) applications. Integrating optical stimulation with recording capability further enhances the selectivity of neural stimulation. We have developed a system enabling the local delivery of optical stimuli and the simultaneous electrical measuring of the neural activities in a closed-loop approach.
Approach:
The signal analysis is performed online through the implementation of a template matching algorithm. The system performance is demonstrated with the recorded data and in awake rats.
Main Results:
Specifically, the neural activities are simultaneously recorded, detected, classified online (through spike sorting) from 32 channels, and used to trigger a light emitting diode light source using generated TTL signals.
Significance:
A total processing time of 8 ms is achieved, suitable for optogenetic studies of brain mechanisms online.
