Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

3.4K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
3.4K
Circadian Rhythms and Gene Regulation02:19

Circadian Rhythms and Gene Regulation

2.1K
2.1K
Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

497
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
497
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

1.4K
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
1.4K
Biological Clocks and Seasonal Responses02:45

Biological Clocks and Seasonal Responses

36.0K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
36.0K
Homeostatic Imbalance01:10

Homeostatic Imbalance

33.2K
Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...
33.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Voces Latinas: A Qualitative Study of Cultural Values and Sleep Health, Insights from Latina Community Health Workers.

Hispanic health care international : the official journal of the National Association of Hispanic Nurses·2026
Same author

Initiation of first-generation antihistamines during pregnancy and gestational restless legs syndrome: a secondary analysis of the nuMoM2b cohort.

American journal of obstetrics & gynecology MFM·2026
Same author

Protocol for Nuestro Sueño: A randomized trial of a couples-based intervention to improve PAP adherence and sleep health among Hispanic patients beginning positive airway pressure (PAP) and their partners.

Sleep medicine·2026
Same author

Actigraphic estimates of sleep duration in those reporting sleeping less than 7 h.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026
Same author

Sleep Optimization to Improve Glycemic Targets in Adults With Type 1 Diabetes: A Randomized Controlled Parallel Intervention Trial.

Diabetes care·2026
Same author

Circadian Rest-Activity Rhythms, Cognition, and Alzheimer Disease Dementia in Adults With Down Syndrome.

Neurology·2026
Same journal

Reductions in posttraumatic stress disorder re-experiencing frequency from repetitive transcranial magnetic stimulation combined with Cognitive Processing Therapy.

International review of psychiatry (Abingdon, England)·2026
Same journal

Continuous theta burst stimulation to the frontal pole durably decreases medial frontoamygdala connectivity.

International review of psychiatry (Abingdon, England)·2026
Same journal

What are the arguments for and against recognizing 'terminal' anorexia nervosa? A narrative review.

International review of psychiatry (Abingdon, England)·2026
Same journal

Behavioral addictions in adolescents in Latin America: a narrative review of prevalence, mental health comorbidities, and gaps in care.

International review of psychiatry (Abingdon, England)·2026
Same journal

Persistent suicidality: a concept analysis using Rodgers' evolutionary approach.

International review of psychiatry (Abingdon, England)·2026
Same journal

Extending the evidence for Scrambler Therapy to reduce pain in chemotherapy-induced peripheral neuropathy.

International review of psychiatry (Abingdon, England)·2026
See all related articles

Related Experiment Video

Updated: Apr 28, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

13.3K

Circadian misalignment and health.

Kelly Glazer Baron1, Kathryn J Reid

  • 1Feinberg School of Medicine, Northwestern University , Chicago, Illinois USA.

International Review of Psychiatry (Abingdon, England)
|June 4, 2014
PubMed
Summary
This summary is machine-generated.

Circadian misalignment, or disrupted biological rhythms, is linked to increased risks for physical and mental health disorders. Understanding these disruptions is key to preventing diseases associated with modern lifestyles.

More Related Videos

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

603
Circadian Entrainment of Drosophila Melanogaster
07:12

Circadian Entrainment of Drosophila Melanogaster

Published on: June 3, 2020

5.8K

Related Experiment Videos

Last Updated: Apr 28, 2026

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments
08:36

Collecting Sleep, Circadian, Fatigue, and Performance Data in Complex Operational Environments

Published on: August 8, 2019

13.3K
Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings
06:39

Through-the-Wall Blood Sampling Method to Minimize Sleep Disruption in Clinical Settings

Published on: June 13, 2025

603
Circadian Entrainment of Drosophila Melanogaster
07:12

Circadian Entrainment of Drosophila Melanogaster

Published on: June 3, 2020

5.8K

Area of Science:

  • Chronobiology
  • Sleep Medicine
  • Metabolic Health

Background:

  • Circadian rhythms are endogenous 24-hour cycles influencing physiology and behavior.
  • Circadian misalignment encompasses disruptions in sleep-wake, feeding, and central/peripheral rhythms.
  • Early research focused on sleep timing, but expanded definitions include peripheral clock gene disruptions.

Purpose of the Study:

  • To define and evaluate circadian misalignment in experimental settings.
  • To review evidence linking circadian misalignment to physical and psychiatric disorders.
  • To explore circadian misalignment as a disease risk factor in general and clinical populations.

Main Methods:

  • Review of laboratory and field experiments on circadian misalignment.
  • Analysis of animal model and human studies on misalignment mechanisms.
  • Synthesis of evidence linking misalignment to disease outcomes.

Main Results:

  • Circadian misalignment is associated with dysregulated feeding, hormonal changes, impaired glucose metabolism, and mood disturbances.
  • Evidence links various forms of circadian misalignment to increased risk of cardiovascular disease, diabetes, obesity, cancer, depression, and other psychiatric disorders.
  • Circadian misalignment is a significant risk factor across general and clinical populations.

Conclusions:

  • Circadian misalignment represents a critical factor in the etiology of numerous physical and mental health conditions.
  • Further research into circadian rhythm disruption mechanisms can inform disease prevention and treatment strategies.
  • Recognizing and addressing circadian misalignment is crucial for public health and clinical practice.