Related Experiment Video
Updated: Apr 28, 2026
07:01
Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
Published on: May 16, 2019
8.0K
Pharmacoresistant epilepsy and nanotechnology.
Argelia Rosillo-de la Torre1, Gabriel Luna-Bárcenas1, Sandra Orozco-Suárez1
1Department of Pharmacobiology, Center of Research , Advanced Studies, Mexico.
Frontiers in Bioscience (Elite Edition)
|June 5, 2014
Summary
Nanotechnology offers a promising solution for drug-resistant epilepsy by enhancing antiepileptic drug delivery across the blood-brain barrier. This approach aims to improve treatment outcomes for patients unresponsive to conventional pharmacotherapy.
Area of Science:
- Neurology
- Pharmacology
- Biotechnology
Background:
- Epilepsy is a common neurological disorder impacting quality of life.
- A significant portion of patients (35-40%) exhibit pharmacoresistant epilepsy.
- Multidrug resistance proteins at the blood-brain barrier impede antiepileptic drug efficacy.
Purpose of the Study:
- To review evidence supporting nanotechnology as a strategy to overcome antiepileptic drug resistance.
- To explore how nanotechnology can enhance brain delivery of antiepileptic drugs.
Main Methods:
- Literature review of studies on nanotechnology applications in epilepsy treatment.
- Analysis of mechanisms by which nanocarriers can bypass blood-brain barrier efflux pumps.
Main Results:
- Nanoparticle-based drug delivery systems show potential for improved brain penetration of antiepileptic drugs.
- Targeted delivery via nanotechnology can overcome multidrug resistance protein-mediated efflux.
Conclusions:
- Nanotechnology presents a viable strategy to address pharmacoresistant epilepsy.
- Further research into nanomedicines could lead to novel therapeutic options for refractory epilepsy patients.
More Related Videos
Related Concept Videos
01:08Antiepileptic Drugs: Sodium Channel Blockers
2.3K
Antiepileptic drugs are specialized medications that prevent seizures in individuals diagnosed with epilepsy. These drugs primarily function by blocking the movement of sodium ions through channels in the neuronal membrane, inhibiting the repetitive firing of action potentials often associated with seizures.
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
Sodium channel blockers modulate ion channels, particularly voltage-gated sodium channels. They block only sodium ion movement.
Among the most commonly prescribed antiepileptic drugs are...
2.3K
01:24Epilepsy and Seizures: Overview
1.7K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.7K
01:14Antiepileptic Drugs: Glutamate Antagonists
1.3K
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
1.3K
01:18Antiepileptic Drugs: GABAergic Pathway Potentiators
1.7K
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
1.7K
01:20Antiepileptic Drugs: Potassium Channel Activators
1.0K
Ezocgabine or retigabine, an antiepileptic drug of remarkable efficacy, has revolutionized the management of seizures. It is a potassium channel activator, explicitly targeting the family of Q subtype potassium channels. It enhances the transmembrane potassium currents, regulating neuronal excitability. This action stabilizes the resting membrane potential, a pivotal factor in mitigating the hyperexcitability that characterizes epilepsy.
Ezogabine has gained approval as an adjunctive treatment...
Ezogabine has gained approval as an adjunctive treatment...
1.0K
01:20Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
1.2K
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
1.2K