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Updated: Apr 28, 2026

Constructing Cyclic Peptides Using an On-Tether Sulfonium Center
Published on: September 28, 2022
Rational construction of triazole/urea based peptidomimetic macrocycles as pseudocyclo-β-peptides and studies on
Abhijit Ghorai1, Samanth Reddy K, Basudeb Achari
1Chemistry Division, CSIR-Indian Institute of Chemical Biology , Kolkata, 700032, India.
Abstract:
A tandem macro-dimerization reaction via a Cu(I) catalyzed azide/alkyne cycloaddition reaction has been employed to construct triazole/urea based peptidomimetic macrocycles considered as pseudocyclo-β-peptides. Introduction of one particular chirality in the peptide backbone can alter the conformation as well as nature of self-assembly from cyclic D-,L-,α-peptide to cyclo-β-peptide. One of them (16a) forms antiparallel dimers while the other (16b) undergoes higher order aggregation to form a nanorod structure.
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