Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiovascular Drugs: Classification based on Therapeutic Indications01:18

Cardiovascular Drugs: Classification based on Therapeutic Indications

4.2K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
4.2K
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

804
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
804
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

942
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
942
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

3.3K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.3K
Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

1.7K
Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.7K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.7K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endothelial oestrogen-myocardial cyclic guanosine monophosphate axis critically determines angiogenesis and cardiac performance during pressure overload.

Cardiovascular research·2024
Same author

Remote Cardiac Rehabilitation With Wearable Devices.

Korean circulation journal·2023
Same author

Tie2-Cre-Induced Inactivation of Non-Nuclear Estrogen Receptor-α Signaling Abrogates Estrogen Protection Against Vascular Injury.

JACC. Basic to translational science·2023
Same author

Effect of the cation structure on cellulose dissolution in aqueous solutions of organic onium hydroxides.

Physical chemistry chemical physics : PCCP·2020
Same author

A large-scale cohort study of long-term cardiac rehabilitation: A prospective cross-sectional study.

International journal of cardiology·2020
Same author

Estrogen Receptor-α Non-Nuclear Signaling Confers Cardioprotection and Is Essential to cGMP-PDE5 Inhibition Efficacy.

JACC. Basic to translational science·2020

Related Experiment Video

Updated: Apr 28, 2026

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

1.6K

IgG4-related cardiovascular disorders.

Miyu Tajima1, Ryozo Nagai, Yukio Hiroi

  • 1Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.

International Heart Journal
|June 6, 2014
PubMed
Summary

Immunoglobulin4 (IgG4)-related disease is a systemic inflammatory condition. Early detection and tailored treatment, including corticosteroids and potential surgery, are crucial for managing IgG4-related cardiovascular disorders.

Area of Science:

  • Rheumatology
  • Cardiology
  • Immunology

Background:

  • Immunoglobulin4 (IgG4)-related disease is a systemic inflammatory condition.
  • It affects multiple organs, including the cardiovascular system, impacting patient prognosis.
  • Cardiovascular involvement necessitates early detection and management.

Purpose of the Study:

  • To highlight the significance of IgG4-related cardiovascular disorders.
  • To discuss diagnostic approaches and treatment strategies.
  • To emphasize the need for individualized treatment plans.

Main Methods:

  • Diagnostic tools include Coronary CT, echocardiography, (18)FDG-PET imaging, serum IgG4 measurement, and tissue biopsy.
  • Minor salivary gland biopsy is recommended when cardiovascular biopsy is challenging.

More Related Videos

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

2.5K
Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

2.0K

Related Experiment Videos

Last Updated: Apr 28, 2026

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding
10:39

Rat Model of Right-Sided Cardiac Remodeling and Arrhythmia Using Pulmonary Artery Banding

Published on: August 30, 2024

1.6K
Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice
04:45

Real-Time Electrocardiogram Monitoring During Treadmill Training in Mice

Published on: May 5, 2022

2.5K
Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
09:36

Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia

Published on: December 22, 2023

2.0K
  • Treatment involves high-dose corticosteroids, with potential need for immunosuppressants and surgery.

    • Main Results:

    • IgG4-related cardiovascular disorders require prompt diagnosis and management.
    • Corticosteroids are effective for active inflammation but not established lesions.
    • Relapse is common, and surgical intervention may be necessary for aneurysms.

    Conclusions:

    • IgG4-related cardiovascular disorders demand careful consideration of corticosteroid dosage, immunosuppressants, and surgical options.
    • Treatment requires a personalized, case-by-case approach.
    • Effective management can improve patient outcomes.