A large-scale cohort study of long-term cardiac rehabilitation: A prospective cross-sectional study

Atsuko Nakayama1, Masatoshi Nagayama2, Hiroyuki Morita3

  • 1Department of Cardiovascular Medicine, The University of Tokyo; Department of Cardiovascular Medicine, Sakakibara Heart Institute.

Insights

Long-term cardiac rehabilitation (CR) significantly reduces mortality and major adverse cardiovascular events (MACE) compared to short-term CR. Extended CR programs offer superior cardiovascular outcomes for patients.

Area of Science:

  • Cardiology
  • Rehabilitation Medicine
  • Public Health

Background:

  • Limited research exists on the long-term therapeutic effects of cardiac rehabilitation (CR).
  • Large-scale data on cardiovascular outcomes following extended CR programs are lacking.

Purpose of the Study:

  • To evaluate the effectiveness of long-term supervised cardiac rehabilitation (CR) on cardiovascular outcomes.
  • To compare mortality and major adverse cardiovascular events (MACE) across different durations of CR.

Main Methods:

  • A cohort study of 9981 patients undergoing CR between 2004 and 2015.
  • Patients were categorized into three groups based on CR duration: acute phase (Phase I), recovery phase (≤150 days, Phase II), and maintenance phase (>150 days, Phase III).
  • Propensity score matching was employed to compare outcomes between groups.

Main Results:

  • The Phase III group (long-term CR) demonstrated significantly lower risks of death (HR 0.47-0.64) and MACE (HR 0.48-0.70) compared to Phase I and II groups.
  • Patients in Phase II (recovery phase CR) showed improved survival compared to Phase I (acute phase CR).
  • Subgroups including females, patients with dyslipidemia, smokers, and those with coronary artery bypass graft or heart failure experienced better survival in Phase III compared to Phase II.

Conclusions:

  • Long-term supervised CR is more effective than short-term CR for patients with cardiovascular diseases.
  • Extended CR programs provide superior cardiovascular protection and improved survival rates.
Abstract

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