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Updated: Dec 25, 2025

A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
Published on: April 19, 2019
A large-scale cohort study of long-term cardiac rehabilitation: A prospective cross-sectional study
Atsuko Nakayama1, Masatoshi Nagayama2, Hiroyuki Morita3
1Department of Cardiovascular Medicine, The University of Tokyo; Department of Cardiovascular Medicine, Sakakibara Heart Institute.
Insights
Long-term cardiac rehabilitation (CR) significantly reduces mortality and major adverse cardiovascular events (MACE) compared to short-term CR. Extended CR programs offer superior cardiovascular outcomes for patients.
Area of Science:
- Cardiology
- Rehabilitation Medicine
- Public Health
Background:
- Limited research exists on the long-term therapeutic effects of cardiac rehabilitation (CR).
- Large-scale data on cardiovascular outcomes following extended CR programs are lacking.
Purpose of the Study:
- To evaluate the effectiveness of long-term supervised cardiac rehabilitation (CR) on cardiovascular outcomes.
- To compare mortality and major adverse cardiovascular events (MACE) across different durations of CR.
Main Methods:
- A cohort study of 9981 patients undergoing CR between 2004 and 2015.
- Patients were categorized into three groups based on CR duration: acute phase (Phase I), recovery phase (≤150 days, Phase II), and maintenance phase (>150 days, Phase III).
- Propensity score matching was employed to compare outcomes between groups.
Main Results:
- The Phase III group (long-term CR) demonstrated significantly lower risks of death (HR 0.47-0.64) and MACE (HR 0.48-0.70) compared to Phase I and II groups.
- Patients in Phase II (recovery phase CR) showed improved survival compared to Phase I (acute phase CR).
- Subgroups including females, patients with dyslipidemia, smokers, and those with coronary artery bypass graft or heart failure experienced better survival in Phase III compared to Phase II.
Conclusions:
- Long-term supervised CR is more effective than short-term CR for patients with cardiovascular diseases.
- Extended CR programs provide superior cardiovascular protection and improved survival rates.
Background:
Few studies have evaluated the therapeutic effect of long-term cardiac rehabilitation (CR) and no large-scale survey of cardiovascular outcomes after long-term CR is reported.
Methods:
This cohort study included 9981 patients undergoing CR from 2004 to 2015. Patients who had supervised CR were divided into three groups according to CR duration: up to acute phase (until discharge, Phase I group), up to recovery phase (≤150 days, Phase II group), and up to maintenance phase (>150 days, Phase III group). Using propensity score matching, mortality and major adverse cardiovascular events (MACE) were compared among the groups.
Results:
Follow-up period was 4.9 ± 3.0 years. Adult patients were divided into three groups (Phase I group: n = 4649, Phase II group: n = 3271, and Phase III group: n = 731). After propensity score matching, the risk of death and MACE was extremely lower in Phase III group than in Phase I or Phase II group (death: HR 0.47, P < 0.01, HR 0.64, P < 0.01, and MACE: HR 0.48, P < 0.01, HR 0.70, P < 0.01). Most patients in Phase II group had better survival than those in Phase I group. Subpopulations of female patients and those with dyslipidemia, smoking history, coronary artery bypass graft, or heart failure had better survival in Phase III group than in Phase II group.
Conclusions:
Long-term supervised CR for patients with cardiovascular diseases is more effective than short-term CR.
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