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Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
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Coding variants in TREM2 increase risk for Alzheimer's disease

Sheng Chih Jin1, Bruno A Benitez1, Celeste M Karch2

  • 1Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid Ave. B8134, St. Louis, MO 63110, USA.

Human Molecular Genetics
|June 6, 2014
PubMed
Summary

Rare variants in the triggering receptor expressed on myeloid 2 (TREM2) gene significantly increase Alzheimer's disease risk. This study identified novel TREM2 variants associated with AD, reinforcing its role in neurodegeneration.

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