Related Experiment Video
Updated: Apr 28, 2026

Isolation and Characterization of Adult Cardiac Fibroblasts and Myofibroblasts
Published on: March 12, 2020
Serum magnesium concentration is inversely associated with fibroblast growth factor 23 in haemodialysis patients
Akira Iguchi1, Yasuo Watanabe, Noriaki Iino
1Department of Internal Medicine, Ojiya General Hospital, Niigata, Japan.
Aim:
Fibroblast growth factor 23 is reported to be a pivotal regulator for the chronic kidney disease-mineral bone disorders, working in coordinated ways with phosphate, calcium, and parathyroid hormone. However, whether there is a relationship between fibroblast growth factor 23 and magnesium is currently unclear. To address this, we performed a cross-sectional observational study in haemodialysis patients.
Methods:
We measured the serum levels of fibroblast growth factor 23, magnesium and other factors that are implicated in chronic kidney disease-mineral bone disorders in 225 haemodialysis patients.
Results:
Simple correlation analysis showed that fibroblast growth factor 23 was not correlated with magnesium. However, upon multiple regression analysis, a significant negative correlation was found between fibroblast growth factor 23 and magunesium (b = -0.164, P = 0.0020). Moreover, the levels of fibroblast growth factor 23 in patients treated with magnesium oxide had significantly lower levels than those without magnesium oxide.
Conclusion:
We speculate that the magnesium is a potential regulator of fibroblast growth factor 23 levels in haemodialysis patients. Our data suggest that follow-up studies to elucidate the molecular mechanisms that underlie this relationship are warranted.
Related Concept Videos
Serum Studies: Renal Function Tests
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
Chronic Kidney Disease III: Interprofessional Care
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate
Roles of Electrolytes: Calcium and Phosphate
The calcium concentration in blood plasma is primarily...
Hemodialysis III: Nursing Management
