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Stapled Vasoactive Intestinal Peptide (VIP) Derivatives Improve VPAC2 Agonism and Glucose-Dependent Insulin Secretion

Fabrizio Giordanetto1, Jefferson D Revell2, Laurent Knerr1

  • 1Departments of Medicinal Chemistry and DMPK, AstraZeneca R&D, CVMD iMed , Mölndal, Pepparedsleden 1, SE-431 83 Mölndal, Sweden.

ACS Medicinal Chemistry Letters
|June 6, 2014
PubMed

Keywords:
VIPVPACglucose toleranceinsulin secretionlactamized peptidepeptide agonistring-closing metathesisstapled peptidevasoactive intestinal peptide

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