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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles

Yingcai Wang1, Jiwen Jim Liu1, Paul J Dransfield1

  • 1Department of Therapeutic Discovery, Metabolic Disorders, Translational Sciences, Amgen Inc. , 1120 Veterans Boulevard, South San Francisco, California 94080, United States and One Amgen Center Drive, Thousand Oaks, California 91320, United States.

ACS Medicinal Chemistry Letters
|June 6, 2014
PubMed

Keywords:
AM-1638AM-5262AMG 837FFA1FFAR1GPR40full agonistspirocyclestricyclic

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