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Development of New Therapeutic Applications Using Microfluidics
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Systems biology approach to developing "systems therapeutics".

Greg Maguire1

  • 1The SRM Molecular Foundry at UCSD, BioRegenerative Sciences, Inc. , San Diego, California 92014, United States.

ACS Medicinal Chemistry Letters
|June 6, 2014
PubMed
Summary

A new "systems therapeutics" approach uses systems biology to target multiple pathways, moving beyond traditional single-target drug discovery for biological breakthroughs.

Area of Science:

  • Drug discovery and development
  • Systems biology
  • Therapeutic technologies

Background:

  • Traditional drug development relies on reductionist methods, focusing on single molecular targets within isolated pathways.
  • Current systems biology applications often still result in single-pathway interventions, limiting holistic treatment potential.

Purpose of the Study:

  • To introduce and define "systems therapeutics" as a novel biological model.
  • To highlight the shift from reductionist approaches to a systems-based strategy in drug development.
  • To propose a new paradigm for developing interventions that act on multiple biological pathways simultaneously.

Main Methods:

  • Analysis of existing drug development models.
  • Comparison with advancements in quantum physics (e.g., "Copenhagen View" vs. systems-based models).

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  • Conceptual framework development for systems therapeutics.

    • Main Results:

    • Identified limitations of the standard reductionist drug discovery model.
    • Drew parallels between breakthroughs in physics and emerging biological models.
    • Proposed "systems therapeutics" as a technology acting on multiple pathways.

    Conclusions:

    • Systems therapeutics represents a significant departure from conventional drug discovery.
    • This new model leverages systems biology for developing multi-pathway interventions.
    • The emergence of systems therapeutics promises new breakthroughs in biological treatments.